The Anti-PP (Pancreatic Polypeptide) (23-2D3) Mouse IgG MoAb Antibody from IBL- America is a Mouse Monoclonal antibody. This antibody recognizes Homo Sapiens, and Human antigen. The Anti-PP (Pancreatic Polypeptide) (23-2D3) Mouse IgG MoAb Antibody has been validated for the following applications: Immunohistochemistry.
Description
Pancreatic Polypeptide (PP) is a 36 amino acid polypeptide that is secreted by PP cells (F cells or γ cells) from the islets of Langerhans of the pancreas and is classified as a NPY family peptide along with Peptide YY (PYY) and Neuropeptide Y (NPY). The receptors of these NPY family consist of 5 subtypes such as Y1, Y2, Y4, Y5 and Y6 and PP has an especially high affinity with the Y4 receptor. It has been known as a satiety factor that suppresses appetite by acting on the Y4 receptor in the hypothalamus. Recently, it has been reported that PP possibly acts as a blood glucose control factor that suppresses the secretion of glucagon by acting on the Y4 receptor of alpha cells after glucose loading